… as antibacterial agents. 2. Synthesis and structure-activity relationships of 1, 6, 7-trisubstituted 1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acids, including …

J Matsumoto, T Miyamoto, A Minamida…

Index: Matsumoto; Miyamoto; Minamida; Nishimura; Egawa Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 292 - 301

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Citation Number: 118

Abstract

The title compounds having nitro, amino, cyano, chloro, or fluoro as the C-6 substituent were prepared. Introduction of the chloro and cyano groups at C-6 was accomplished by the Sandmeyer reaction of 6-amino-1, 8-naphthyridine derivatives 9 via their 6-diazonium salts 10. The reaction was extended to the synthesis of the 6-fluor0 analogues 20, involving the Balz-Schiemann reaction of the diazonium tetrafluoroborate 19. Furthermore, a series of ...