N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetilase (HDAC) inhibitors

…, R Pezzi, T Brunetti, G Battistuzzi, M Di Marzo…

Index: Giannini, Giuseppe; Marzi, Mauro; Pezzi, Riccardo; Brunetti, Tiziana; Battistuzzi, Gianfranco; Marzo, Maria Di; Cabri, Walter; Vesci, Loredana; Pisano, Claudio Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 8 p. 2346 - 2349

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Citation Number: 26

Abstract

With the aim to discover novel HDAC inhibitors with high potency and good safety profiles, we have designed a small library based on a N-hydroxy-(4-oxime)-cinnamide scaffold. We describe the synthesis of these novel compounds and some preliminary in vitro cytotoxic activity on three tumor cell lines, NB4, H460 and HCT116, as well as their inhibitory activity against class I, II and IV HDAC. Several 4-oxime derivatives demonstrated a promising ...