Pyrazolo [1, 5-a] pyridines: synthetic approaches to a novel class of antiherpetics
BA Johns, KS Gudmundsson, EM Turner, SH Allen…
Index: Johns, Brian A.; Gudmundsson, Kristjan S.; Turner, Elizabeth M.; Allen, Scott H.; Jung, David K.; Sexton, Connie J.; Boyd Jr., F. Leslie; Peel, Michael R. Tetrahedron, 2003 , vol. 59, # 45 p. 9001 - 9011
Full Text: HTML
Citation Number: 51
Abstract
Synthesis of a novel class of 7-amino-3-pyrimidinyl-pyrazolo [1, 5-a] pyridine antiherpetic compounds is described. The synthetic methodology is designed to allow for rapid analog synthesis around the C-3 and C-7 positions of the pyrazolo [1, 5-a] pyridine. The 7- chloropyrazolo [1, 5-a] pyridine D, produced through an azirine rearrangement, served as a key building block. Two complementary methodologies for construction of the C-3 ...