[2-(Guanidino)-anilides and related compounds. Synthesis and anthelmintic effect. 3. Anthelmintics]

H Wollweber, H Kölling, E Niemers, A Widdig…

Index: Wollweber; Kolling; Niemers; et al. Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 5 p. 531 - 542

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Citation Number: 11

Abstract

Anilides bearing a guanidino, thioallophanato, isothioallophanato or amidino group in the ortho position were synthesised (6) for investigations of their anthelmintic effects, and tested against sheep trichostrongylides. The most active anilides are those containing a 5-alkylthio, 5-alkylsulphinyl (alkyl= C3H7, C4H9), 5-phenylthio, 5-phenylsulphinyl or 4- phenylsulphonyloxy group, and a guanidino group substituted at both nitrogen atoms by a ...