Nickel??Catalyzed Intramolecular Nucleophilic Addition of Aryl or Vinyl Chlorides to α??Ketoamides Through C Cl Bond Activation

JX Hu, H Wu, CY Li, WJ Sheng, YX Jia…

Index: Hu, Jin-Xiu; Wu, Hao; Li, Chuan-Ying; Sheng, Wei-Jian; Jia, Yi-Xia; Gao, Jian-Rong Chemistry - A European Journal, 2011 , vol. 17, # 19 p. 5234 - 5237

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Citation Number: 4

Abstract

Organopalladium and organonickel intermediates derived from aryl or vinyl halides through oxidative addition to Pd0 and Ni0 complexes predominantly act as electrophiles in carbon– carbon bond-forming reactions.[1] In contrast, their nucleophilic reactivity has received much less attention; however, the development of the direct catalytic nucleophilic reaction of aryl or vinyl halides with electrophilic partners is very attractive because it omits the ...