Caged mitochondrial uncouplers that are released in response to hydrogen peroxide

C Quin, L Robertson, SJ McQuaker, NC Price…

Index: Quin, Caroline; Robertson, Linsey; McQuaker, Stephen J.; Price, Nicholas C.; Brand, Martin D.; Hartley, Richard C. Tetrahedron, 2010 , vol. 66, # 13 p. 2384 - 2389

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Citation Number: 15

Abstract

Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncouplers 2, 4-dinitrophenol (DNP) and carbonylcyanide p- trifluoromethoxyphenylhydrazone (FCCP) from caged states with second order rate constants of 10 (±0.8) M− 1s− 1 and 64.8 (±0.6) M− 1s− 1, respectively. The trigger ...