The Journal of organic chemistry

A Direct and Mild Formylation Method for Substituted Benzenes Utilizing Dichloromethyl Methyl Ether–Silver Trifluoromethanesulfonate

K Ohsawa, M Yoshida, T Doi

Index: Ohsawa, Kosuke; Yoshida, Masahito; Doi, Takayuki Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3438 - 3444

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Citation Number: 12

Abstract

A silver trifluoromethanesulfonate (AgOTf)-promoted direct and mild formylation of benzenes has been developed. The reaction utilizing dichloromethyl methyl ether (Cl2CHOMe) and AgOTf powerfully formylated various substituted benzenes under temperature conditions as low as− 78° C without losing the protecting groups on the phenolic hydroxyl group.