Catalytic enantioselective addition of MeMgBr and other Grignard reagents to aldehydes

E Fernández??Mateos, B Maciá…

Index: Fernandez-Mateos, Emilio; MacIa, Beatriz; Ramon, Diego J.; Yus, Miguel European Journal of Organic Chemistry, 2011 , # 34 p. 6851 - 6855

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Citation Number: 11

Abstract

Abstract Herein, we report an efficient catalyst for the challenging enantioselective addition of MeMgBr to aldehydes. Unprecedented yields and enantioselectivities are achieved in the reaction with a broad range of aldehydes. Moreover, a variety of Grignard reagents can be also added to aromatic and aliphatic aldehydes in good yields and enantioselectivities in a simple one-pot procedure under mild conditions.

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