The total large-scale synthesis of argiopine

AA Formanovsky, IS Popova, IV Mikhura

Index: Formanovsky; Popova; Mikhura Russian Journal of Bioorganic Chemistry, 2009 , vol. 35, # 6 p. 752 - 758

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Abstract

Abstract The total large-scale synthesis of a natural toxin argiopine, a polymethylenepolyamine derivative, was developed. It consisted of 26 stages and included three key block schemes. Most of the stages proceeded quantitatively, which excluded the necessity of using the chromatographic separation of intermediates.