Templating effects in aristolochene synthase catalysis: elimination versus cyclisation
…, V González, M Senske, RK Allemann
Index: Faraldos, Juan A.; Gonzalez, Veronica; Senske, Michael; Allemann, Rudolf K. Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6920 - 6923
Full Text: HTML
Citation Number: 10
Abstract
Analysis of the products generated by mutants of aristolochene synthase from P. roqueforti (PR-AS) revealed the prominent structural role played by the aliphatic residue Leu 108 in maintaining the productive conformation of farnesyl diphosphate to ensure C1–C10 (σ- bond) ring-closure and hence (+)-aristolochene production.
Related Articles:
[Brieger,G. et al. Journal of Organic Chemistry, 1969 , vol. 34, p. 3789 - 3791]
[Brieger,G. et al. Journal of Organic Chemistry, 1969 , vol. 34, p. 3789 - 3791]
[Brieger,G. et al. Journal of Organic Chemistry, 1969 , vol. 34, p. 3789 - 3791]
[Brieger,G. et al. Journal of Organic Chemistry, 1969 , vol. 34, p. 3789 - 3791]
[Yasuda,A. et al. Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 1752 - 1756]