N 5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces …

…, R Steadman, KD Patefield, JJ Bunker, AL Atkin…

Index: Johnson, Brad; Steadman, Rachel; Patefield, Krista D.; Bunker, Jeffrey J.; Atkin, Audrey L.; Dussault, Patrick Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2351 - 2353

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Abstract

A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N5- phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.