Palladium-catalyzed heck alkynylation of benzyl chlorides

CH Larsen, KW Anderson, RE Tundel, SL Buchwald

Index: Larsen, Catharine H.; Anderson, Kevin W.; Tundel, Rachel E.; Buchwald, Stephen L. Synlett, 2006 , # 18 p. 2941 - 2946

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Citation Number: 19

Abstract

Abstract An efficient and general protocol for the palladium-catalyzed Heck alkynylation of benzyl chlorides was developed. A catalyst system comprised of PdCl 2 (CH 3 CN) 2 and 2- dicyclohexylphosphino-2′, 4′, 6′-triisopropylbiphenyl (XPhos), with Cs 2 CO 3 as the base, efficiently couples a wide range of functionalized terminal alkynes and substituted benzyl chlorides at 65 C. We have also demonstrated that the corresponding aryl allene ...