Novel Synthesis of 2, 4-Dihydro-5-amino [1, 2, 4] triazol-3-ones from 1, 3-Disubstituted Thioureas

C Jin, C Liu, W Su

Index: Jin, Can; Liu, Chuangwei; Su, Weike Synlett, 2009 , # 4 p. 607 - 610

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Citation Number: 4

Abstract

Abstract A facile two-step synthesis of 2, 4-dihydro-5-amino-[1, 2, 4] triazol-3-ones is described. Firstly, 1, 3-disubstituted thioureas reacted with bis (trichloromethyl) carbonate (BTC) in the presence of a base such as NaHCO 3 to form the intermediate 4-(arylimino)-1, 3-