The Aldol??Grob Reaction: Regioselective Synthesis of (E)??Alkenes from Aldehydes and Ketones with Ytterbium Triflate Catalysis

…, F Epifano, F Maltese, MC Marcotullio

Index: Curini, Massimo; Epifano, Francesco; Maltese, Federica; Marcotullio, Maria Carla European Journal of Organic Chemistry, 2003 , # 9 p. 1631 - 1634

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Citation Number: 7

Abstract

In 1993 Sakai9 and co-workers described a novel BF 3 etherate catalysed one-pot tandem aldol condensation-Grob fragmentation sequence. Recently Kabalka and co-workers10 have published a more detailed study of the aldol-Grob reaction, incorporating the effect of different Lewis acids, solvents and substrate structure on the reaction pathway.10 The aldol-Grob reaction has been applied successfully in the synthesis of some natural products and is the key step in ...

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