Reversible photocontrol of peptide conformation with a rhodopsin-like photoswitch

M Blanco-Lomas, S Samanta, PJ Campos…

Index: Blanco-Lomas, Marina; Samanta, Subhas; Campos, Pedro J.; Woolley, G. Andrew; Sampedro, Diego Journal of the American Chemical Society, 2012 , vol. 134, # 16 p. 6960 - 6963

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Citation Number: 39

Abstract

Reversible photocontrol of biomolecules requires chromophores that can efficiently undergo large conformational changes upon exposure to wavelengths of light that are compatible with living systems. We designed a benzylidene–pyrroline chromophore that mimics the Schiff base of rhodopsin and can be used to introduce light-switchable intramolecular cross- links in peptides and proteins. This new class of photoswitch undergoes an∼ 10 Å ...