Cyclisierungen mit cyanthioacetamid in gegenwart von schwefel

K Gewald, R Schindler

Index: Gewald, K.; Schindler, R. Journal fuer Praktische Chemie (Leipzig), 1990 , vol. 332, # 2 p. 223 - 228

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Citation Number: 44

Abstract

A bstract. Cyanothioacetoamide 1 reacts with sulphur in the presence of triethylamiiie to form the 2, 5-diamino-thiophene derivative 3 and in the presence of sodium ethoxide the 1, 4- dihydropyridine derivative 2, respectively. 3 easily undergoes ring opening to yield the butadiene derivative 6. Catalyzed by amine from 1, cyclic ketones, and sulphur the 2-spiro [thieno [2, 3-d] pyrimidine-4-thiones] 8 arise. Analogously to other cyanoacetic acid ...