Synthesis of methyl-substituted xanthotoxol to clarify prooxidant effect of methyl on radical-induced oxidation of DNA

C Xiao, ZG Song, ZQ Liu

Index: Xiao, Chuan; Song, Zhi-Guang; Liu, Zai-Qun European Journal of Medicinal Chemistry, 2010 , vol. 45, # 6 p. 2559 - 2566

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Citation Number: 11

Abstract

4-Methyl-8-hydroxylpsoralen (MXan) and 4, 9-dimethyl-8-hydroxylpsoralen (DMXan) were synthesized in order to clarify the effect of methyl on the antioxidant effectiveness of xanthotoxol (8-hydroxylpsoralen, Xan), which were assessed by bleaching β-carotene in linoleic acid–Triton emulsion, by interacting with 2, 2′-azinobis (3-ethylbenzothiazoline-6- sulfonate) cationic radical (ABTS+), 2, 2′-diphenyl-1-picrylhydrazyl radical (DPPH), and ...