8-Methoxypsoralen-nucleic acid photoreaction. Effect of methyl substitution on pyrone vs. furan photoaddition

D Kanne, H Rapoport, JE Hearst

Index: Kanne, David; Rapoport, Henry; Hearst, John E. Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 531 - 534

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Citation Number: 35

Abstract

Results The psoralen-modified nucleic acids' were hydrolyzed enzymatically, and the resulting hydrolysis mixture contained the psoralen-modified nucleosides along with a much larger quantity of material due to the unmodified nucleosides. Isolation of the individual adducts from this complex sample matrix was accomplished by high-performance liquid chromatography (HPLC). The results of earlier NMR studies4+ on 8-methoxypsoralen (8- ...