A study of the delivery-targeting concept applied to antineoplasic drugs active on human osteosarcoma. I. Synthesis and biological activity in nude mice carrying …

…, O Fodstad, G Schwartsmann, HR Hendriks

Index: Sturtz; Appere; Breistol; Fodstad; Schwartsmann; Hendriks European Journal of Medicinal Chemistry, 1992 , vol. 27, # 8 p. 825 - 833

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Citation Number: 52

Abstract

Abstract With the aim of verifying the concept of osteotic vectorisation, synthesis of three methotrexate (MTX) gem-diphosphonic analogues (compounds A, B and C) was performed. These molecules were tested on BALB/c and NIH III mice previously grafted with subcutaneous implants of OHS, TTX p7 and/or TTX p11 human osteosarcoma cell lines. Antineoplasic activity of compound B and C (active compounds) was compared to the ...

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