Total synthesis of the potent antifungal agents bengazole C and E

Á Enríquez-García, SV Ley

Index: Enriquez-Garcia, Alvaro; Ley, Steven V. Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 6 p. 887 - 900

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Citation Number: 7

Abstract

Abstract The bengazoles are marine natural products with unique structure, containing two oxazole rings flanking a single carbon. They show very potent antifungal activity. The total syntheses of bengazole C and E are described following a convergent route which involves diastereoselective cycloaddition of an appropriately substituted nitrile oxide with a butane-1, 2-diacetal-protected alkenediol as the key step.

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