Glycomimetic selectin inhibitors:(α-D-mannopyranosyloxy) methylbiphenyls

B Dupré, H Bui, IL Scott, RV Market, KM Keller…

Index: Dupre, Brian; Bui, Huong; Scott, Ian L.; Market, Robert V.; Keller, Karin M.; Beck, Pamela J.; Kogan, Timothy P. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 5 p. 569 - 572

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Citation Number: 52

Abstract

A novel class of biphenyl-based compounds were investigated for their ability to inhibit sialyl Lewis X (sLex) dependent binding of HL-60 cells to E-and P-selectin fusion proteins. Compounds (2b) and (2h) demonstrated improved binding as compared to both the natural ligand sLex and a previously reported inhibitor TBC-265 (1, R= 3-CH2CO2H).

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