QSAR modeling, synthesis and bioassay of diverse leukemia RPMI-8226 cell line active agents

…, S Slavov, SR Tala, I Stoyanova-Slavova

Index: Katritzky, Alan R.; Girgis, Adel S.; Slavov, Svetoslav; Tala, Srinivasa R.; Stoyanova-Slavova, Iva European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5183 - 5199

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Citation Number: 20

Abstract

A rigorous QSAR modeling procedure employing CODESSA PRO descriptors has been utilized for the prediction of more efficient anti-leukemia agents. Experimental data concerning the effect on leukemia RPMI-8226 cell line tumor growth of 34 compounds (treated at a dose of 10μM) was related to their chemical structures by a 4-descriptor QSAR model. Four bis (oxy) bis-urea and bis (sulfanediyl) bis-urea derivatives (4a, 4b, 8, 11a) ...

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