Versatile Synthesis of Isoquinolines and Isochromenes by Pd??Catalyzed Oxidative Carbonylation of (2??Alkynyl) benzylideneamine Derivatives

B Gabriele, L Veltri, V Maltese, R Spina…

Index: Gabriele, Bartolo; Veltri, Lucia; Maltese, Vito; Spina, Rosella; Mancuso, Raffaella; Salerno, Giuseppe European Journal of Organic Chemistry, 2011 , # 28 p. 5626 - 5635

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Citation Number: 7

Abstract

Abstract Isoquinoline-4-carboxylic esters 3 and isochromene-4-carboxylic esters 4 have been conveniently prepared by direct PdI 2-catalyzed oxidative heterocyclization/ alkoxycarbonylation of readily available (2-alkynylbenzylidene) amine derivatives. In particular,(2-alkynylbenzylidene)(tert-butyl) amines 2 selectively afforded isoquinoline derivatives 3 by N-cyclization, whereas N-(2-alkynylbenzylidene)-N′-phenylhydrazines 5 ...