The discovery and development of a safe, practical synthesis of ABT-869

…, MJ Rozema, A Chu-Kung, J Gandarilla…

Index: Kruger, Albert W.; Rozema, Michael J.; Chu-Kung, Alexander; Gandarilla, Jorge; Haight, Anthony R.; Kotecki, Brian J.; Richter, Steven M.; Schwartz, Albert M.; Wang, Zhe Organic Process Research and Development, 2009 , vol. 13, # 6 p. 1419 - 1425

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Citation Number: 16

Abstract

The discovery, development and implementation of two chemical routes to ABT-869 is reported. Optimization of the first-generation heterocycle formation and Suzuki coupling is briefly described. Key features of the second-generation synthesis include the ...