Synthesis and anti-inflammatory effect of chalcones and related compounds

HK Hsieh, TH Lee, JP Wang, JJ Wang, CN Lin

Index: Hsieh, Hsin-Kaw; Lee, Tai-Hua; Wang, Jih-Pyang; Wang, Jeh-Jeng; Lin, Chun-Nan Pharmaceutical Research, 1998 , vol. 15, # 1 p. 39 - 46

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Citation Number: 256

Abstract

Abstract Purpose. Mast cell and neutrophil degradations are the important players in inflammatory disorders. Combined with potent inhibition of chemical mediators released from mast cells and neutrophil degranulations, it could be a promising anti-inflammatory agent. 2′, 5′-Dihydroxychalcone has been reported as a potent chemical mediator and cyclooxygenase inhibitor. In an effort to continually develop potent anti-inflammatory ...