A Unified Synthesis of Bifunctional 4??Substituted??1, 2, 3, 4??tetrahydroisoquinoline Derivatives

M Carmen Bernabeu, J Luis Díaz…

Index: Bernabeu, M. Carmen; Diaz, Jose Luis; Jimenez, Oscar; Lavilla, Rodolfo Synthetic Communications, 2004 , vol. 34, # 1 p. 137 - 149

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Citation Number: 3

Abstract

Abstract Starting from a single, commercially available bromoisoquinoline, convenient (multigram) syntheses of 4??substituted??1, 2, 3, 4??tetrahydroisoquinoline derivatives have been developed. The compounds thus prepared show suitable substitution patterns for further derivatization and constitute a new family of compounds of potential pharmacological interest.