Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole

…, M Macchia, A Martinelli, S Rapposelli…

Index: Rossello, Armando; Bertini, Simone; Lapucci, Annalina; Macchia, Marco; Martinelli, Adriano; Rapposelli, Simona; Herreros, Esperanza; Macchia, Bruno Journal of Medicinal Chemistry, 2002 , vol. 45, # 22 p. 4903 - 4912

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Citation Number: 101

Abstract

Some new oxime ethers of types 7 and 8, in which the methyleneaminoxy group, C NO, of oxiconazole 6 is in an inverted atomic sequence, were synthesized and tested for their antifungal activities. Among them, the type 7 compounds, such as the N-ethoxy-morpholino- substituted derivatives 7l-o (Table 1), showed good antifungal properties against the Candida strains tested, with minimum inhibitory concentration (MIC) values similar to ...

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