An approach to the tricyclic core of madangamines based upon a biogenetic scheme

…, MT Martin, A Chiaroni, M Bénéchie, C Marazano

Index: Han, Min Tong; Martin, Marie-Therese; Chiaroni, Angele; Benechie, Michel; Marazano, Christian Organic Letters, 2005 , vol. 7, # 12 p. 2437 - 2440

Full Text: HTML

Citation Number: 17

Abstract

A short synthesis of intermediates possessing the tricyclic core of natural madangamines, bioactive alkaloids found in marine sponges, is described. The key reaction entails the condensation of the sodium salt of diethylacetonedicarboxylate with a dihydropyridinium salt derivative. This new approach is modeled on a biogenetic proposal linking madangamines to ircinals, related alkaloids occurring in sponges of the same order.

Related Articles:

N-Heteroarylmethyl-5-hydroxy-1, 2, 5, 6-tetrahydropyridine-3-carboxylic acid a novel scaffold for the design of uncompetitive α-glucosidase inhibitors

[Long, Sha; Stefani, Francesca Romana; Biondi, Stefano; Ghiselli, Giancarlo; Panunzio, Mauro Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5811 - 5822]

Convenient Formal Synthesis of (±)??Paroxetine

[Chavan, Subhash P.; Khobragade, Dushant A.; Pathak, Ashok B.; Kalkote, Uttam R. Synthetic Communications, 2007 , vol. 37, # 18 p. 3143 - 3149]

Convenient Formal Synthesis of (±)??Paroxetine

[Chavan, Subhash P.; Khobragade, Dushant A.; Pathak, Ashok B.; Kalkote, Uttam R. Synthetic Communications, 2007 , vol. 37, # 18 p. 3143 - 3149]

Convenient Formal Synthesis of (±)??Paroxetine

[Chavan, Subhash P.; Khobragade, Dushant A.; Pathak, Ashok B.; Kalkote, Uttam R. Synthetic Communications, 2007 , vol. 37, # 18 p. 3143 - 3149]

Convenient Formal Synthesis of (±)??Paroxetine

[Chavan, Subhash P.; Khobragade, Dushant A.; Pathak, Ashok B.; Kalkote, Uttam R. Synthetic Communications, 2007 , vol. 37, # 18 p. 3143 - 3149]

More Articles...