3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

…, L Arve, H Prinz, H Waldmann, H Kessler

Index: Weide, Timo; Arve, Lars; Prinz, Heino; Waldmann, Herbert; Kessler, Horst Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 59 - 63

Full Text: HTML

Citation Number: 80

Abstract

In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.

Related Articles:

Remarkable optical induction in the reduction of. alpha.-oxo esters with B-(3-pinanyl)-9-borabicyclo [3.3. 1] nonane. Synthesis of. alpha.-hydroxy esters of 100% …

[Brown, Herbert C.; Pai, Ganesh G.; Jadhav, Prabhakar K. Journal of the American Chemical Society, 1984 , vol. 106, # 5 p. 1531 - 1533]

Stereocontrolled synthesis of d-α-hydroxy carboxylic acid from l-amino acids

[Kunz, Horst; Lerchen, Hans-Georg Tetrahedron Letters, 1987 , vol. 28, # 17 p. 1873 - 1876]

References for 2-4

[Mikhaleva,I.I. et al. J. Gen. Chem. USSR (Engl. Transl.), 1968 , vol. 38, p. 1228 - 1239,1184 - 1193]

More Articles...