Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors

WP Jackson, PJ Islip, G Kneen, A Pugh…

Index: Jackson; Islip; Kneen; Pugh; Wates Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 499 - 500

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Citation Number: 74

Abstract

In the search for novel inhibitors of the 5-lipoxygenase (5-LO) pathway of arachidonic acid metabolism, we have had occasion to look at several series of hydroxamic acids, two examples of which are described within. The 5-LO pathway leads to several compounds with extremely potent biological activities: leukotriene B4 (LTB4) has been shown1 to be a potent chemotactic agent in vivo, while the peptido leukotrienes LTC4 and LTD4 are ...