Helvetica chimica acta

Ringtransformationen von 3??substituiertem 5??Trifluormethyl??1, 3, 4??thiadiazol??2 (3H)??on mit Nucleophilen

H Kristinsson, T Winkler, M Mollenkopf

Index: Kristinsson, Haukur; Winkler, Tammo; Mollenkopf, Max Helvetica Chimica Acta, 1983 , vol. 66, # 8 p. 2714 - 2728

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Citation Number: 7

Abstract

Summary The 3-chlormethyl-5-trifluoromethyl-l, 3, 4-thiadiazolone 3 undergoes a ring transformation to 3-acylated 2, 3-dihydro-l, 3, 4-thiadiazoles 4 with many nucleophiles. Upon formal replacement of the chloromethyl group in the 3-position of 3 by an extended bromoalkyl chain (+ 9a-c), the reaction with nucleophiles yields 4-acylated 5, 6-dihydro-