Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611

…, P Demerseman, A Kruczynski, C Etiévant…

Index: Daley, Laurent; Guminski, Yves; Demerseman, Pierre; Kruczynski, Anna; Etievant, Chantal; Imbert, Thierry; Hill, Bridget T.; Monneret, Claude Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4475 - 4485

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Citation Number: 26

Abstract

A series of 3-amino-and 3-alkylamino-2-deoxy-β-d-ribo-and β-d-arabino-glycosides of 4'- demethylepipodophyllotoxin have been synthesized by means of an improved trimethylsilyliodide procedure for the podophyllotoxin-4'-demethylepipodophyllotoxin conversion, an efficient and high yielding synthesis of silyl glycoside donors of 3-azido-2, 3- dideoxy-β-d-ribo-and β-d-arabino-hexopyranosides and stereoselective glycosylations. In ...