Synthesis of Some Novel D??Glucuronic Acid Acetylated Derivatives as Potential Anti??Tumor Agents

…, YM El??Kholy, SH El??Sayed, T El??Naggar

Index: El-Nezhawy, Ahmed O.H.; Adly, Frady G.; Eweas, Ahmed F.; Hanna, Atef G.; El-Kholy, Yehya M.; El-Sayed, Shahenaz H.; El-Naggar, Tarek B.A. Archiv der Pharmazie, 2011 , vol. 344, # 10 p. 648 - 657

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Citation Number: 6

Abstract

Abstract A structurally diverse series of Δ 4, 5-uronamide derivatives have been chemically synthesized starting from D-glucuronic acid itself by means of acetylation, activation, amide bond formation and base-catalyzed elimination protocols. Structure elucidation for all products along with optimization of the synthetic steps is described. The synthesized compounds were evaluated for their in-vitro anti-tumor activity against MCF-7, TK-10 and ...

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