Bromine analogs of quinoxidine, dioxidine, and amides of di-N-oxides of 3-hydroxymethylquinoxaline-2-carboxylic acid

…, NP Solov'eva, LM Polukhina, NY Moskalenko…

Index: Musatova, I. S.; Elina, A. S.; Solov'eva, N. P.; Polukhina, L. M.; Moskalenko, N. Yu.; Pershin, G. N. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 11 p. 779 - 784 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 11 p. 1307 - 1312

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Abstract

Amides of 3-hydroxymethyl-7-bromoquinoxaline-2-carboxylic acid di-N-oxide (XXIIIa-i) were synthesized from 2-carbethoxy-3-methyl-7-bromoquinoxaline-di-N-oxide(V), which was in turn prepared by a known method: the reaction of 5 (6)-bromobenzofuroxane (VI) with esters of acetoacetic acid in the presence of various basic reagents [4, 5]. These authors recommended the use of the 7-and 6-bromo isomers of 2-carbalkoxy-3-methylquinoxaline ...