Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from α-aminosuberic acid
…, MP Glenn, GM Boyle, JDA Tyndall…
Index: Glenn, Matthew P.; Kelso, Michael J.; Tyndall, Joel D. A.; Fairlie, David P. Journal of the American Chemical Society, 2003 , vol. 125, # 3 p. 640 - 641
Full Text: HTML
Citation Number: 47
Abstract
Chemotherapy in the last century was characterized by cytotoxic drugs that did not discriminate between cancerous and normal cell types and were consequently accompanied by toxic side effects that were often dose limiting. The ability of differentiating agents to selectively kill cancer cells or transform them to a nonproliferating or normal phenotype could lead to cell-and tissue-specific drugs without the side effects of current ...
Related Articles:
[Heinsoo; Raidaru; Linask; Jarv; Zetterstrom; Langel Tetrahedron Asymmetry, 1995 , vol. 6, # 9 p. 2245 - 2247]
[Leggio, Antonella; Liguori, Angelo; Procopio, Antonio; Sindona, Giovanni Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 13 p. 1969 - 1971]
[Siciliano, Carlo; De Marco, Rosaria; Guidi, Ludovica Evelin; Spinella, Mariagiovanna; Liguori, Angelo Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10575 - 10582]
[Siciliano, Carlo; De Marco, Rosaria; Guidi, Ludovica Evelin; Spinella, Mariagiovanna; Liguori, Angelo Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10575 - 10582]