Total syntheses of the metabolites of schizandrin
…, Y Ikeya, H Mitsuhashi, M Maruno, T Wakamatsu
Index: Tanaka, Masahide; Ikeya, Yukinobu; Mitsuhashi, Hiroshi; Maruno, Masao; Wakamatsu, Takeshi Tetrahedron, 1995 , vol. 51, # 43 p. 11703 - 11724
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Citation Number: 26
Abstract
The total syntheses of the metabolites of schizandrin were achieved. The tetracyclic lactone intermediates (13a–e) were prepared in optically pure form by the oxidative coupling reaction of the corresponding 3-benzyl-1-benzylidenebutyrolactones. Mukaiyama hydration of 13b afforded hydroxylactone (14), which was converted into SZ-M3 (4). The introduction of C6, 7-diol moiety, which is common to the metabolites (4–11), was carried out by the ...
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