Tetrahedron Letters

Solid phase asymmetric alkylation reactions using 2-imidazolidinone chiral auxiliary

QPB Nguyen, JN Kim, TH Kim

Index: Nguyen, Quynh Pham Bao; Kim, Jae Nyoung; Kim, Taek Hyeon Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4015 - 4018

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Citation Number: 13

Abstract

A novel solid supported 2-imidazolidinone chiral auxiliary was prepared from O-benzyl-l- tyrosine and Wang resin. Asymmetric alkylation reactions in the solid phase proceeded with excellent stereoselectivities, which were even higher than those observed in the conventional solution phase method.

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