NO-Donors, part 3: nitrooxyacylated thiosalicylates and salicylates–synthesis and biological activities

…, A Hacker, E Noack, G Kojda, J Lehmann

Index: Endres, Stefan; Hacker, Andreas; Noack, Eike; Kojda, Georg; Lehmann, Jochen European Journal of Medicinal Chemistry, 1999 , vol. 34, # 11 p. 895 - 901

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Citation Number: 15

Abstract

Organic nitrates release nitric oxide when incubated with thiosalicylic acid. S- Nitrooxyacylated esters and amides of thiosalicylic acid, together with the corresponding salicylates, were synthesized in order to perform a first in vitro evaluation of these new nitrate-thiol-hybrid prodrugs. These prodrugs might release NO in vivo after biotransformation without the use of endogenous reductives. None of these prodrugs ...