Synthesis and biological evaluation of sulfur-containing cinnamate and salicylate derivatives

CC Chiang, TC Chang, HJ Tsai, LY Hsu

Index: Chiang, Chih-Chia; Chang, Tsu-Chung; Tsai, Hou-Jen; Hsu, Ling-Yih Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 3 p. 369 - 373

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Citation Number: 6

Abstract

UV irradiation induced formation of reactive oxygen radical species and matrix metalloproteinases (MMPs) are thought to be involved in photo-damage to the skin. MMP-1 is the major collagenolytic enzyme responsible for collagen destruction in skin tissue. To develop new anti-photoaging agents, a series of 2, 2′-dithiocinnamate derivatives and 2, 2′-dithio or 2-thiobenzoate derivatives were designed and synthesized. The biological ...