European Journal of Organic Chemistry

An Expedient Synthesis of Olfactory Lactones by Intramolecular Hydroacylalkoxylation Reactions

LA Adrio, KKM Hii

Index: Adrio, Luis A.; Hii, King Kuok Mimi European Journal of Organic Chemistry, 2011 , # 10 p. 1852 - 1857

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Citation Number: 1

Abstract

Abstract A series of 4, 5-disubstituted γ-lactones, including whisky and cognac lactones, was synthesised in four steps from a readily available chiral precursor. By using an intramolecular hydroacylalkoxylation reaction in the final step, a correlation between the (E)/(Z) configuration of the precursor and the product distribution has been established, for the first time, in this type of cyclisation reactions.