Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3)

SD Kuduk, RK Chang, CN Di Marco…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 14 p. 4255 - 4258

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Citation Number: 8

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Merck Research ... A significant medical need remains for new analgesics 1 to treat those who suffer from chronic pain due to damage or persistent inflammation of neuronal or somatic tissue, and the ...

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

[Spicer, Julie A.; Lena, Gersande; Lyons, Dani M.; Huttunen, Kristiina M.; Miller, Christian K.; O'Connor, Patrick D.; Bull, Matthew; Helsby, Nuala; Jamieson, Stephen M. F.; Denny, William A.; Ciccone, Annette; Browne, Kylie A.; Lopez, Jamie A.; Rudd-Schmidt, Jesse; Voskoboinik, Ilia; Trapani, Joseph A. Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9542 - 9555]

Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3)

Abstract

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