DNA cleavage by di-and trihydroxyalkylbenzenes. Characterization of products and the roles of O2, Cu (II), and alkali

US Singh, RT Scannell, H An, BJ Carter…

Index: Singh, Udai S.; Scannell, Ralph T.; An, Haoyun; Carter, Barbara J.; Hecht, Sidney M. Journal of the American Chemical Society, 1995 , vol. 117, # 51 p. 12691 - 12699

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Citation Number: 97

Abstract

Abstract: Several 5-alkyl-l, 3-dihydroxybenzene (5-alkylresorcinol, 1) and 6-alky1-1, 2, 4- trihydroxybenzene (2) derivatives were prepared and used to study the mechanism by which such compounds effect Cu (I1)-dependent DNA strand scission. Comparison of the methyl, n- pentyl, n-undecyl, and n-hexadecyl derivatives in each structural series indicated that the efficiency of DNA cleavage increased with increasing length of the alkyl substituent. DNA ...