Improved functional group compatibility in the palladium-catalyzed synthesis of aryl amines

MC Harris, X Huang, SL Buchwald

Index: Harris, Michele C.; Huang, Xiaohua; Buchwald, Stephen L. Organic Letters, 2002 , vol. 4, # 17 p. 2885 - 2888

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Citation Number: 102

Abstract

The use of Pd2dba3 with bulky, electron-rich ligands 1 or 2 and LiN (TMS) 2 as the base for the coupling of amines with aryl halides containing hydroxyl, amide, or enolizable keto groups is described. This protocol expands the utility of palladium-catalyzed CN bond formation by allowing for the use of aryl halides containing these functional groups, obviating the need for protecting group manipulations.