Thermal cycloaddition of 1, 3, 5-triazine with enamines: regiospecific pyrimidine annulation

DL Boger, J Schumacher, MD Mullican…

Index: Boger, Dale L.; Schumacher, Jane; Mullican, Michael D.; Patel, Mona; Panek, James S. Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2673 - 2675

Full Text: HTML

Citation Number: 55

Abstract

A recent study of Neunhoeffer and Bachmann has demonstrated that 1, 3, 5-triazine (2) undergoes a rapid and regiospecific cycloaddition reaction with ynamines, and the subsequent loss of hydrogen cyanide provided a simple pyrimidine~ ynthesis.~ In addition, Neunhoeffer has shown that a symmetrical enamine, l-pyrrolidinocyclopentene, participates in a similar cycloaddition reaction with 2 and affords the pyrimidine product 3b after loss of ...

Related Articles:

Highly active and recyclable silica gel-supported palladium catalyst for mild cross-coupling reactions of unactivated heteroaryl chlorides

[Lee, Dong-Hwan; Jung, Ji-Young; Jin, Myung-Jong Green Chemistry, 2010 , vol. 12, # 11 p. 2024 - 2029]

Highly active and recyclable silica gel-supported palladium catalyst for mild cross-coupling reactions of unactivated heteroaryl chlorides

[Lee, Dong-Hwan; Jung, Ji-Young; Jin, Myung-Jong Green Chemistry, 2010 , vol. 12, # 11 p. 2024 - 2029]

An unprecedented approach to 4, 5-disubstituted pyrimidine derivatives by a ZnCl2-catalyzed three-component coupling reaction

[Sasada, Toshiaki; Kobayashi, Fuminori; Sakai, Norio; Konakahara, Takeo Organic Letters, 2009 , vol. 11, # 10 p. 2161 - 2164]

Scope and Limitation for FeSO 4-Mediated Direct Arylation of Heteroarenes with Arylboronic Acids and Its Synthetic Applications

[Bulletin of the Chemical Society of Japan, , vol. 87, # 2 p. 301 - 313]

Fast and green one-pot multicomponent synthesis of a library of pyrrolo [1, 2-c] pyrimidines under microwave irradiation

[Georgescu, Emilian; Georgescu, Florentina; Draghici, Constantin; Cristian, Liliana; Popa, Marcel Mirel; Dumitrascu, Florea Combinatorial Chemistry and High Throughput Screening, 2013 , vol. 16, # 10 p. 851 - 857]

More Articles...