Synthesis and antihypertensive activity of 4-(substituted-carbonylamino)-2H-1-benzopyrans

VA Ashwood, F Cassidy, MC Coldwell…

Index: Ashwood; Cassidy; Coldwell; Evans; Hamilton; Howlett; Smith; Stemp Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2667 - 2672

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Citation Number: 40

Abstract

The synthesis and antihypertensive activity of a series of novel 4-(substituted- carbonylamino)-Wl-benzoppen-3-ols, administered orally to conscious spontaneously hypertensive rats, are described. Optimum activity was observed for compounds with alkyl, amino, or aryl groups flanking the carbonyl group. Of the alkyl and amino series the most potent compounds contained the methyl and methylamino groups, respectively. Several ...