NOVEL SYNTHESIS OF CARBOCYCLIC OXETANOCIN ANALOGS (2-ALKOXY-C. OXT-A) AND THEIR TUBE FORMATION ACTIVITIES OF HUMAN …

N Sakakibara, I Tsukamoto, T Tsuruta, M Takata…

Index: Sakakibara, Norikazu; Tsukamoto, Ikuko; Tsuruta, Takashi; Takata, Maki; Konishi, Ryoji; Maruyama, Tokumi Heterocycles, 2012 , vol. 85, # 5 p. 1105 - 1116

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Citation Number: 4

Abstract

Abstract–We succeeded in the effective synthesis of five types of 2-alkoxy-C. OXT-A analogs (9, 10a–d) by applying the de novo synthesis of 2-alkoxyadenosine derivatives (2), which was developed in our laboratory. For these synthesized compounds, the angiogenic activity was evaluated using human umbilical vein endothelial cells. Four products (10a–d) enhanced the activity of the cell; in particular, 2-methoxy-C. OXT-A (10a) and 2-isopropoxy ...