Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent

GJ Atwell, BF Cain, BC Baguley, GJ Finlay…

Index: Atwell; Cain; Baguley; Finlay; Denny Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1481 - 1485

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Citation Number: 129

Abstract

The synthesis and biological activities of representatives of a new class of antitumor agent, the N-[2-(dialkyl-amino) ethyl]-9-aminoacridine-4-carboxamides, are reported. Members of this class are stable and very water soluble with high levels of in vitro and in vivo antitumor activity. The compounds bind tightly to double-stranded DNA by intercalation, but the requirements for antitumor activity are more restrictive. They depend critically on the ...