Tetrahedron

Palladium-catalyzed carbonylative cyclization of Baylis–Hillman adducts. An efficient approach for the stereoselective synthesis of 3-alkenyl phthalides

F Coelho, D Veronese, CH Pavam, VI de Paula…

Index: Coelho, Fernando; Veronese, Demetrius; Pavam, Cesar H.; de Paula, Vanderlei I.; Buffon, Regina Tetrahedron, 2006 , vol. 62, # 18 p. 4563 - 4572

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Citation Number: 53

Abstract

A palladium-mediated carbonylative cyclization reaction of Baylis–Hillman adducts is disclosed. This simple, efficient and straightforward sequence leads to the formation of an array of 3-alkenylphthalides with different substitution patterns on the aromatic ring, with good chemical yields and selectivities.

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