1, 5-Benzoheteroazepines through eco-friendly general condensation reactions

M Nardi, A Cozza, L Maiuolo, M Oliverio, A Procopio

Index: Nardi, Monica; Cozza, Annalisa; Maiuolo, Loredana; Oliverio, Manuela; Procopio, Antonio Tetrahedron Letters, 2011 , vol. 52, # 38 p. 4827 - 4834

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Citation Number: 29

Abstract

Abstract Condensation reactions of o-phenylenediamine and 2 equiv of acetone produce biaryl-substituted 1, 5-benzodiazepines. The synthetic protocol shows general applicability since similar reaction of o-phenylenediamines, o-aminophenol, and o-aminothiophenol with ketones or chalcones leads to formation of functionalized 1, 5-benzoheteroazepines in good to excellent yields. The synthetic protocol fulfills many green-chemical requirements using ...