Gold (I)-catalyzed synthesis of 1, 5-benzodiazepines directly from o-phenylenediamines and alkynes

J Qian, Y Liu, J Cui, Z Xu

Index: Qian, Jianqiang; Liu, Yunkui; Cui, Jianhai; Xu, Zhenyuan Journal of Organic Chemistry, 2012 , vol. 77, # 9 p. 4484 - 4490

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Citation Number: 36

Abstract

The traditional strategies for the synthesis of 1,5-benzodiazepines basically rely on the condensation reactions of o-phenylenediamines with α,β-unsaturated carbonyl compounds,(5) β-haloketones,(6) or ketones(5a, 7) (Scheme 1, paths a–c). These reactions can offer effective methods for the synthesis of 1,5-benzodiazepines. However, they inevitably suffer from unsatisfactory atom economy. Therefore, from the sustainable and atom-economic synthesis point of ...